Anaesthetic drugs & techniques
Remimazolam versus sevoflurane for general anaesthesia: A meta-analysis with trial sequential analysis of haemodynamic and clinical outcomes
Pooled result · Intraoperative hypotension (binary event)Result — go to the resultRelative risk 0.38 95% CI 0.25–0.57Authors' conclusion
Remimazolam was associated with a lower incidence of intraoperative hypotension compared with sevoflurane, while differences in MAP and HR were limited to specific time points.
Study context
- Population
- Patients receiving general anaesthesia (GA) or deep sedation (mean age 61.6 years; 36.8% laparoscopic procedures)
- Participants
- 739 patients · 12 RCTs
- Comparison
- Remimazolam vs sevoflurane for GA
- Outcome
- Intraoperative hypotension (binary event)
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
0.38
95% CI 0.25–0.57
P < 0.001
Remimazolam vs Sevoflurane
RR 0.38 (95% CI 0.25–0.57); P < 0.001
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| PONV · up to 24 h | 0.65 (0.47–0.90) | P = 0.01 | |
| PONV · 72 h | 0.66 (0.50–0.89) | ||
| 0.512Relative risk (log scale) |
| Outcome | Mean difference (mmHg) | P value |
|---|---|---|
| MAP · 30 min after start of surgery | 6.05 | P < 0.03 |
HR
- Higher with remimazolam at 30 min
- P = 0.04
- Higher with remimazolam at end of surgery
- P < 0.01
- Higher with remimazolam in PACU
- P < 0.01
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Remimazolam versus sevoflurane for general anaesthesia: A meta-analysis with trial sequential analysis of haemodynamic and clinical outcomes. Eur J Anaesthesiol. Published 4 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →