Effect of combination of remimazolam and sevoflurane on elderly patients’ recovery quality from general anesthesia after laparoscopic abdominal surgery: a randomized controlled trial
Authors' conclusion
Combining remimazolam with sevoflurane improves postoperative recovery quality in elderly patients undergoing laparoscopic abdominal surgery.
Study context
- Population
- Patients aged 60 to 80 years scheduled for laparoscopic gallbladder or hernia surgery102 analysed
- Participants
- 109 patients
- Comparison
- Remimazolam + sevoflurane vs remimazolam alone for GA maintenance
- Primary endpoint
- QoR-15 score
Methodological details7 patients lost to follow-up
- 7 patients lost to follow-up
Primary result
As reported in the abstract
QoR-15 and physical comfort scores · POD1
Group S
135.0
bracketed, type not stated 8.0
Group R
132.0
bracketed, type not stated 11.0
P = 0.004
Secondary outcomes
| Outcome | Group S | Group R | P value |
|---|---|---|---|
| QoR-15 and physical comfort scores · POD3Higher in Group S | 143.0 (bracketed, type not stated 6.0) | 141.0 (bracketed, type not stated 7.0) | P = 0.007 |
| Remifentanil useLess in Group S | P = 0.021 | ||
| Extubation timeSignificantly longer in Group S | P = 0.048 |
Induction time and perioperative hemodynamic variables
- No significant differences between the groups
Safety
Postoperative adverse events
- No significant differences between the groups
Original publication
Effect of combination of remimazolam and sevoflurane on elderly patients’ recovery quality from general anesthesia after laparoscopic abdominal surgery: a randomized controlled trial. Perioper Med (Lond). Published 13 February 2025. doi:10.
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