Pediatric anesthesia & critical care
Effect of Remimazolam on Emergence Delirium in Children Undergoing Laparoscopic Surgery: A Double-blinded Randomized Trial
Authors' conclusion
Both continuous infusion and single bolus administration of remimazolam can effectively reduce the occurrence of emergence delirium in children.
Study context
- Population
- Children aged 1 to 6 yr undergoing laparoscopic surgeryrandomised
- Participants
- 120 children
- Comparison
- Remimazolam continuous infusion or single bolus vs saline
- RCn = 40
- RBn = 39
- Cn = 40reference
- Primary endpoint
- Incidence of emergence delirium (Pediatric Anesthesia Emergence Delirium scale)
Methodological detailsdouble-blinded, three-arm
- Double-blinded
- Three-arm
Primary result
As reported in the abstract
Each group vs CRelative risk (95% CI)P value
RC
0.14(0.04–0.59)
P = 0.001RB
0.22(0.07–0.71)
P = 0.003Secondary outcomes
Events
| Outcome | RC | RB | C | RR (95% CI) | P value | |
|---|---|---|---|---|---|---|
| Rescue propofol in PACURC vs C | 2 | 2 | 10 | 0.20 (0.05–0.86) | P = 0.012 | |
| Rescue propofol in PACURB vs C | 0.21 (0.05–0.88) | P = 0.014 | ||||
| 0.050.21520Relative risk (log scale) |
Recovery time
- No differences detected
Safety
Adverse effects
- No differences detected
Original publication
Effect of Remimazolam on Emergence Delirium in Children Undergoing Laparoscopic Surgery: A Double-blinded Randomized Trial. Anesthesiology. Published 16 May 2024. doi:10.
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