Pediatric anesthesia & critical care
Intravenous Lidocaine for Postoperative Pain in Children Undergoing Tonsillectomies: A Double-Blinded, Randomized, Placebo-Controlled Trial
Primary result · Adjusted PACU morphine consumption per kg of body weightResult — go to the resultDifference −0.01 MME/kg 95% CI −0.07 to 0.04Authors' conclusion
The analysis showed no evidence for a clinical benefit of intraoperative lidocaine infusion in children undergoing tonsillectomy.
Study context
- Population
- Children aged 4–10 years undergoing tonsillectomy with or without adenoidectomy88 completed
- Participants
- 90 children
- Comparison
- IV lidocaine vs saline
- Lidocainen = 44
- Salinen = 44reference
- Primary endpoint
- Opioid consumption in milligram morphine equivalents (MME) in the PACU
Methodological detailsprospective, double-blinded, placebo-controlled
- Prospective
- Double-blinded
- Placebo-controlled
Primary result
As reported in the abstract
Adjusted PACU morphine consumption per kg of body weight
Difference
−0.01 MME/kg
95% CI −0.07 to 0.04
P = 0.627
Between groups
difference −0.01 MME/kg (95% CI −0.07 to 0.04); P = 0.627
Per kg of body weight, as printed
Secondary outcomes
Total morphine use
| Difference (MME/kg) (95% CI) | P value | ||
|---|---|---|---|
| Between groups | −0.03 (−0.08 to 0.03) | P = 0.360 | |
| −0.1−0.0500.05Difference, MME/kg (linear scale) |
PACU pain (Children's Hospital of Eastern Ontario Pain Scale), emergence agitation (Pediatric Anesthesia Emergence Delirium scale), ondansetron dose
- No significant difference
Parent-reported pain, nausea/vomiting, ibuprofen, acetaminophen or opioid use at home · first postoperative week
- No differences
Original publication
Intravenous Lidocaine for Postoperative Pain in Children Undergoing Tonsillectomies: A Double-Blinded, Randomized, Placebo-Controlled Trial. Anesth Analg. Published 23 October 2025. doi:10.
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