Pediatric anesthesia & critical care
Association of perioperative intravenous lignocaine and intraoperative neuromonitoring in adolescent idiopathic scoliosis surgery: a retrospective study
Authors' conclusion
Perioperative IV lignocaine infusion during TIVA for AIS surgery significantly reduced MEP and SSEP amplitudes and prolonged SSEP latency, though lacking clinical significance.
Study context
- Population
- Adolescent idiopathic scoliosis patients undergoing single-stage posterior spinal fusion under total intravenous anaesthesia (TIVA), tertiary university hospital, 2020 to 2023analysed
- Participants
- 115 patients
- Exposure
- Intravenous (IV) lignocaine added to TIVA vs TIVA alone
- Lignocainen = 59
- Standardn = 56reference
- Outcome
- SSEP and MEP amplitude and latency (clinically significant: > 50% amplitude reduction or > 10% latency increase)
- Follow-up
- Five time points T1–T5
Methodological detailsmatched, single-centre
- Matched
- Single-centre
Main finding
As reported in the abstract
MEP and SSEP amplitude and latency
- Motor evoked potential (MEP) amplitudes over right tibialis anterior and bilateral abductor hallucis significantly reduced in the lignocaine group
- p < 0.05
- Significant SSEP amplitude reduction and latency prolongation at the left cortical in the lignocaine group at all time points
- p < 0.05
Observational data: associations, not effects.
Further findings
Intraoperative propofol dose
P = 0.003
Original publication
Association of perioperative intravenous lignocaine and intraoperative neuromonitoring in adolescent idiopathic scoliosis surgery: a retrospective study. Perioper Med (Lond). Published 4 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →