Pediatric anesthesia & critical care
Association of single bolus versus bolus followed by infusion of tranexamic acid with blood loss in adolescent idiopathic scoliosis surgery
Authors' conclusion
TXA when administered as a single bolus or bolus followed by infusion in AIS patients undergoing PSF surgery was associated with similar estimated total surgical blood loss and blood transfusion requirement.
Study context
- Population
- Adolescent idiopathic scoliosis (AIS) patients aged 10–21 years undergoing posterior spinal fusion at a tertiary university hospital, December 2018 to September 2019
- Participants
- 129 patients
- Exposure
- Tranexamic acid (TXA) single bolus vs bolus followed by infusion
- Outcome
- Total estimated blood loss
Methodological detailssingle-centre, All surgeries performed by two senior consultants
- Single-centre
- All surgeries performed by two senior consultants
Main finding
As reported in the abstract
| Group | Value | Range |
|---|---|---|
| Group A | mean 723.3 (SD 279.4) mL | 175.0-1607.0 mL |
| Group B | mean 819.4 (SD 302.6) mL | 330.0-1556.0 mL |
Value
Group Amean 723.3 (SD 279.4) mL
Group Bmean 819.4 (SD 302.6) mL
Range
Group A175.0-1607.0 mL
Group B330.0-1556.0 mL
- Group B vs Group A: P = 0.065 — no difference
Observational data: associations, not effects.
Further findings
- None received blood transfusion
- 0
Safety
- No complications
Original publication
Association of single bolus versus bolus followed by infusion of tranexamic acid with blood loss in adolescent idiopathic scoliosis surgery. Perioper Med (Lond). Published 30 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →