Pediatric anesthesia & critical care
Efficacy and safety of high-dose versus low-dose versus no tranexamic acid in adolescent idiopathic scoliosis surgery: A Bayesian network meta-analysis
Authors' conclusion
Both low and high doses of TXA decrease intraoperative blood loss. Moreover, high doses show a significant reduction in total blood loss.
Study context
- Population
- Adolescent idiopathic scoliosis (AIS) corrective surgery20 studies
- Comparison
- High-dose vs low-dose tranexamic acid (TXA) vs no TXA
- Outcome
- Intraoperative blood loss
Methodological detailsrandom-effects model, non-informative priors, mainly non-randomized studies
- Random-effects model
- Non-informative priors
- Mainly non-randomized studies
Pooled result
As reported in the abstract
MD, ml (95 % CrI)
Low TXA vs ControlCrI
−256.56(−483.7 to −63.07)
High TXA vs ControlCrI
−333.11(−603.3 to −123.18)
High TXA vs Low TXACrI; no difference
−74.79(−349.36 to 178.03)
Further pooled results
| Outcome | MD (ml) (CrI) | |
|---|---|---|
| Total blood lossHigh TXA vs Control | −664.5 (−1330 to −5.41) | |
| −2000−100001000Difference, ml (linear scale) |
Total blood loss
- Low TXA showed no significant difference in total blood loss vs control or high TXA
SUCRA ranking
- High-dose arm showed the highest SUCRA ranking in most network meta-analysis (NMA) outcomes
Original publication
Efficacy and safety of high-dose versus low-dose versus no tranexamic acid in adolescent idiopathic scoliosis surgery: A Bayesian network meta-analysis. J Clin Anesth. Published 11 October 2025. doi:10.
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