Nociception Effect on Frontal Electroencephalogram Waveform and Phase-Amplitude Coupling in Laparoscopic Surgery
Authors' conclusion
Alpha dropout during noxious stimulation is observed in laparoscopic surgeries under sevoflurane. In addition, the modulation index of delta-alpha coupling decreases during noxious stimulation and recovers after the administration of rescue opioids.
Study context
- Population
- Patients undergoing laparoscopic surgery
- Participants
- 34 patients
- Exposure
- Preincision vs postincision, postinsufflation and postopioid phases
- Outcome
- Frontal EEG alpha power percentage and delta-alpha phase-amplitude coupling (MI) during noxious stimulation
Methodological detailsrepeated-measures
- Repeated-measures
Main finding
As reported in the abstract
Alpha power percentage decreased after incision (mean ± SEM, preincision and postincision)
26.27 ± 0.44 and 24.37 ± 0.66
P < .001
Alpha power percentage decreased after insufflation (mean ± SEM, preincision and postinsufflation)
26.27 ± 0.44 and 24.40 ± 0.68
P = .002
Modulation index (MI) of delta-alpha coupling decreased after incision (preincision and postincision)
1.83 ± 0.22 and 0.98 ± 0.14 [MI × 10 3 ]
P < .001
MI of delta-alpha coupling still suppressed during insufflation (preincision and postinsufflation)
1.83 ± 0.22 and 1.17 ± 0.15 [MI × 10 3 ]
P = .044
Observational data: associations, not effects.
Original publication
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