Respiratory failure & ventilation
Analgesia and Sedation Use During Noninvasive Ventilation for Acute Respiratory Failure
Main finding · Intubation or deathResult — go to the resultAverage treatment effect OR 1.38 95% CI 1.35–1.40Authors' conclusion
The use of sedation and analgesia during NIV is common. Medication exposure was associated with increased odds of intubation or death.
Study context
- Population
- Adults (≥ 18 yr) admitted to US hospitals requiring noninvasive ventilation (NIV) for acute respiratory failure, Premier Healthcare Database, 1017 hospitals, January 2010–September 2020
- Participants
- 433,357 adults · 1,017 hospitals
- Exposure
- Sedation or analgesia vs none during NIV
- Outcome
- Intubation or death
Methodological detailsmulticentre, inverse probability weighting
- Multicentre
- Inverse probability weighting
Main finding
As reported in the abstract
Average treatment effect OR
1.38
95% CI 1.35–1.40
Any study medication vs No study medication
average treatment effect OR 1.38 (95% CI 1.35–1.40)
Observational data: associations, not effects.
Further findings
Receipt of sedation or analgesia during NIV
- Any sedation or analgesia
- 26.7%
- Opioids only
- 50,589 (11.7%)
- Benzodiazepines only
- 40,646 (9.4%)
- Opioids and benzodiazepines
- 20,146 (4.6%)
- Dexmedetomidine only
- 1.573 (0.4%)
- Dexmedetomidine plus opioid and/or benzodiazepine
- 2,639 (0.6%)
- 95% CI 26.3%-27.0% for any sedation or analgesia
Intubation or death, all NIV patients
- Intubation or death
- 50,413 (11.6%; 95% CI, 11.5-11.7%)
- Intubation
- 32,301 (7.4%; 95% CI, 7.3-7.6%)
- Death
- 24,140 (5.6%; 95% CI, 5.5-5.7%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Analgesia and Sedation Use During Noninvasive Ventilation for Acute Respiratory Failure. Crit Care Med. Published 20 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →