Pediatric anesthesia & critical care
Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study)
Authors' conclusion
Sedation use may be useful in children with ARF treated with NIV, as it seems to improve clinical parameters and comfort status but may not increase the NIV failure rate or PICU LOS, even though sedated children were more severe at technique initiation in the present sample.
Study context
- Population
- Children under 5 years with acute respiratory failure receiving noninvasive ventilation (NIV), 13 pediatric intensive care unit (PICUs) in Spain, 2021
- Participants
- 457 participants · 13 PICUs
- Exposure
- Sedation vs no sedation during NIV
- Sedationn = 213
- Outcome
- Effects of sedation on clinical parameters, comfort (COMFORT-B), intubation requirement (NIV failure) and PICU LOS
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
NIV failure (endotracheal intubation)
P = 0.092
- Overall NIV success rate
- 95.6%
Observational data: associations, not effects.
Further findings
Independent predictors of NIV failure (multivariate analysis)
| OR (95% CI) | ||
|---|---|---|
| PRISM III score at NIV initiation | 1.408 (1.230–1.611) | |
| Respiratory rate at 3 h | 1.043 (1.009–1.079) | |
| 0.512Odds ratio (log scale) |
PICU length of stay (LOS)
- Correlated with weight, PRISM III score, respiratory rate at 12 h, SpO2 at 3 h, FiO2 at 12 h, NIV failure and NIV duration
Original publication
Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study). Crit Care. Published 11 July 2024. doi:10.
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