Pediatric anesthesia & critical care
Effects of Noninvasive Respiratory Support on Ventilation Distribution During Spontaneous Breathing Sedation in Preschool/School‐Aged Children: An Electrical Impedance Tomography Study
Authors' conclusion
In this specific ventilatory setting, spontaneous breathing sedation resulted in enhanced ventilation inhomogeneity and a reduction in EELI that could be reversed by NIV but not by CPAP.
Study context
- Population
- Preschool/school-aged children under intravenous propofol spontaneous breathing sedation
- Participants
- 13 participants
- Comparison
- Continuous positive airway pressure (CPAP) vs noninvasive ventilation (NIV) (20-min steps) during propofol spontaneous breathing sedation, vs spontaneous breathing before, during and after sedation
- Primary endpoint
- Regional ventilation delay 40% (RVD40%)
Methodological detailssingle-centre, physiological, electrical impedance tomography
- Single-centre
- Physiological
- Electrical impedance tomography
Primary result
As reported in the abstract
RVD40%
- CPAP not effective in restoring RVD40 to SB1 values
- SB-2 vs spontaneous breathing (SB-1): P = 0.014
- NIV vs CPAP: P = 0.009
- NIV vs SB-3: P = 0.015
Secondary outcomes
| Outcome | P value |
|---|---|
| Global index (GI)NIV vs SB-2 · GI decreased | P = 0.035 |
| End-expiratory lung impedance (EELI)NIV vs SB-2 · EELI restored | P = 0.002 |
| Center of ventilation (CoV)NIV vs SB-1 · CoV increased | P = 0.001 |
| Center of ventilation (CoV)NIV vs SB-2 · CoV increased | P = 0.004 |
| Center of ventilation (CoV)NIV vs CPAP · CoV increased | P = 0.004 |
Global index (GI)
- CPAP not effective in restoring GI to SB1 values
End-expiratory lung impedance (EELI)
- CPAP not effective in restoring EELI to SB1 values
Center of ventilation (CoV)
- Ventilation shifted toward ventral lung areas during NIV
Original publication
Effects of Noninvasive Respiratory Support on Ventilation Distribution During Spontaneous Breathing Sedation in Preschool/School‐Aged Children: An Electrical Impedance Tomography Study. Paediatr Anaesth. Published 22 March 2025. doi:10.
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