Analgesic Effectiveness of Liposomal Bupivacaine versus Plain Local Anesthetics for Abdominal Fascial Plane Blocks: A Systematic Review and Meta-analysis of Randomized Trials
Pooled resultResult — go to the resultSMD −0.21 cm.h 95% CI −0.43 to 0.01Authors' conclusion
This systematic review and meta-analysis suggests similar analgesic effectiveness between liposomal bupivacaine and plain local anesthetics when used for fascial plane block of the abdominal wall.
Study context
- Population
- Adults receiving abdominal fascial plane blocks
- Participants
- 1,287 adults · 16 trials
- Comparison
- Liposomal bupivacaine vs Plain local anesthetics
- Liposomal bupivacainen = 667
- Plain local anestheticsn = 620reference
- Outcome
- Area under the curve rest pain
- Follow-up
- 24 to 72 h postoperatively
Methodological detailsHartung-Knapp-Sidik-Jonkman random effects
- Hartung-Knapp-Sidik-Jonkman random effects
Pooled result
As reported in the abstract
SMD
−0.21 cm.h
95% CI −0.43 to 0.01
P = 0.058
Liposomal bupivacaine vs Plain local anesthetics
SMD −0.21 cm.h (95% CI −0.43 to 0.01); P = 0.058
Further pooled results
Subgroup analyses (conflict of interest; mixing of plain local anesthetics with liposomal bupivacaine) (subgroup)
- Results robust to subgroup analysis
Day 2 and day 3 secondary outcomes
- The two groups not different for any day 2 or day 3 secondary outcome
Original publication
Analgesic Effectiveness of Liposomal Bupivacaine versus Plain Local Anesthetics for Abdominal Fascial Plane Blocks: A Systematic Review and Meta-analysis of Randomized Trials. Anesthesiology. Published 5 April 2024. doi:10.
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