Analgesic efficacy of erector spinae plane block versus paravertebral block in lung surgeries—A non‐inferiority randomised controlled trial
Authors' conclusion
This trial demonstrated that a continuous erector spinae plane block was not non-inferior to a continuous paravertebral block for analgesia after lung surgery but resulted in higher levels of postoperative pain and opioid consumption.
Study context
- Population
- Patients undergoing unilateral lung surgeryenrolled at interim analysis
- Participants
- 120 patients
- Comparison
- Continuous Erector Spinae Plane Block (ESPB) vs continuous paravertebral block (PVB) at T5
- Primary endpoint
- Pain on numerical rating scale (NRS) (interaction of three measures); NRS ≥ 7 = analgesia failure; non-inferiority margin 10%
- Follow-up
- 24 h postoperatively
Methodological detailsnon-inferiority, active-controlled, blinded for patients and assessors, interim analysis, Terminated at interim analysis
- Non-inferiority
- Active-controlled
- Blinded for patients and assessors
- Interim analysis
- Terminated at interim analysis
Primary result
Mean NRS over 24 h · 24 h
Difference
−0.67
95% CI −1.29 to −0.05
P = 0.02
By group
ESPB
4.6
mean · SD 3.2
PVB
3.9
mean · SD 2.9
ESPB vs PVB
difference −0.67 (95% CI −1.29 to −0.05); P = 0.02
Non-inferiority margin 10 as printed, not drawn
As reported in the abstract
Further findings
| Outcome | P value |
|---|---|
| NRS analgesia failure · 24 hHigher in ESPB | P < 0.01 |
| Postoperative opioid consumption · 24 hMore in ESPB | P = 0.01 |
Patient satisfaction
- No difference between groups
Original publication
Analgesic efficacy of erector spinae plane block versus paravertebral block in lung surgeries—A non‐inferiority randomised controlled trial. Acta Anaesthesiol Scand. Published 30 August 2023. doi:10.
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