Analysis of exhaled breath to identify critically ill patients with ventilator‐associated pneumonia
Authors' conclusion
Identified volatile organic compounds in the exhaled breath of mechanically ventilated critically ill patients show promise as a useful non-invasive 'rule-out' test for ventilator-associated pneumonia.
Study context
- Population
- Mechanically ventilated critically ill ICU patients started on antibiotics for clinically suspected VAP, recruited within 24 h of treatmentbreath available from 92
- Participants
- 96 participants
- Comparison
- Exhaled breath volatile organic compounds vs respiratory tract microbiological culture for VAP
- Outcome
- Diagnostic performance of exhaled volatile organic compounds as a 'rule-out' test for VAP (reference: culture of pathogenic bacteria in respiratory tract samples)
Methodological detailsproof of concept, Exhaled breath captured on sorbent tubes, analysed by thermal desorption gas chromatography-mass spectrometry, Univariable and multivariable analyses of volatile organic compounds
- Proof of concept
- Exhaled breath captured on sorbent tubes, analysed by thermal desorption gas chromatography-mass spectrometry
- Univariable and multivariable analyses of volatile organic compounds
Performance
As reported in the abstract
Four highest performing candidate biomarkers (benzene, cyclohexanone, pentanol, undecanal)
AUC range across the four biomarkers
0.67 to 0.77
NPV range across the four biomarkers
85% to 88%
Original publication
Analysis of exhaled breath to identify critically ill patients with ventilator‐associated pneumonia. Anaesthesia. Published 3 April 2023. doi:10.
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