Early Detection of Ventilator-associated Pneumonia From Exhaled Breath in Intensive Care Unit Patients
Authors' conclusion
Carbon disulfide associated with gram-negative VAP can be identified on HME filters up to 3 days before the initial clinical suspicion, and approximately a week before culture confirmation.
Study context
- Population
- Intubated ICU patients who developed ventilator-associated pneumonia (VAP)111 heat and moisture exchange (HME) filters
- Participants
- 12 patients
- Comparison
- Volatile organic compounds (VOCs) on HME filters on pneumonia days vs non-pneumonia days
- Outcome
- Association of VOCs on HME filters with presence of VAP
Methodological detailsmatched pairs analysis
- Matched pairs analysis
Performance
As reported in the abstract
Carbon disulfide
Carbon disulfide found in pneumonia-day samples (patients)
11 of 12
AUC ROC for carbon disulfide
0.649
95% CI 0.419–0.88
Original publication
Early Detection of Ventilator-associated Pneumonia From Exhaled Breath in Intensive Care Unit Patients. Ann Surg. Published 26 June 2024. doi:10.
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