Impact of respiratory viruses detection on outcomes in ventilated nosocomial pneumonia: an exposed/unexposed study
Authors' conclusion
In this cohort of patients with bacterial vHAP/VAP, the detection of respiratory viruses did not significantly impact ICU mortality, 3-month mortality, or ICU length of stay.
Study context
- Population
- Intensive care unit (ICU) patients with bacterial ventilated hospital-acquired pneumonia (vHAP) or ventilator-associated pneumonia (VAP), tertiary ICU, 2020–2024; SARS-CoV-2 excluded1:1 matched
- Participants
- 80 patients
- Exposure
- Bacterial and viral detection vs bacterial-only vHAP/VAP
- Bacterial and viraln = 40
- Bacterial-onlyn = 40reference
- Outcome
- Mortality (ICU mortality, 3-month mortality) and other clinical outcomes
Methodological detailsexposed/unexposed, single-centre, tertiary ICU
- Exposed/unexposed
- Single-centre
- Tertiary ICU
Main finding
As reported in the abstract
ICU mortality, 3-month mortality, ICU LOS, duration of mechanical ventilation
3-month mortality, whole cohort
36%
ICU mortality, whole cohort
32%
Median duration of mechanical ventilation, whole cohort (days) [IQR 12-31.5]
21
Median ICU LOS, whole cohort (days) [IQR 13-39.5]
24
Observational data: associations, not effects.
Further findings
Viral pathogens identified in co-infection group
- Rhinovirus/enterovirus (13/40)
- 33%
- Endemic coronaviruses (12/40)
- 30%
- Influenza viruses (4/40)
- 10%
- Parainfluenza viruses (3/10)
- 8%
- Adenovirus (3/10)
- 8%
- Metapneumovirus (2/40)
- 5%
- Respiratory syncytial virus (2/40)
- 5%
- Viruses detected in nasopharyngeal swab (12/30)
- 30%
Original publication
Impact of respiratory viruses detection on outcomes in ventilated nosocomial pneumonia: an exposed/unexposed study. Ann Intensive Care. Published 27 October 2025. doi:10.
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