European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial lower respiratory tract infections (LRTI)
Authors' conclusion
VHAP patients presented the highest mortality among those admitted to the ICU. Multidrug-resistant pathogens frequently cause nosocomial LRTI in this multinational cohort study.
Study context
- Population
- Intensive care unit (ICU) patients with nosocomial LRTI, 13 countries, May 2016–August 2019
- Participants
- 1,060 patients
- Exposure
- Ventilator-associated tracheobronchitis (VAT) vs ventilator-associated pneumonia (VAP) vs ICU hospital-acquired pneumonia (ICU-HAP) vs HAP vs VHAP
- VATn = 160
- VAPn = 556
- ICU-HAPn = 98
- HAPn = 152
- VHAPn = 94
- Outcome
- Mortality
Methodological detailsmultinational, 13 countries
- Multinational
- 13 countries
Main finding
As reported in the abstract
ICU mortality
30.8%
Hospital mortality
37.5%
28-day mortality
27.5%
Observational data: associations, not effects.
Further findings
Microbiology
- Etiological microbiology identified (of 1008 with samples)
- 711 (70.5%)
- Pseudomonas aeruginosa
- 18.4%
- Klebsiella spp
- 14.4%
- Causative pathogen with some antimicrobial resistance pattern
- 382 (36%)
Severity and complications
- VHAP had higher serum procalcitonin (PCT) and Sequential Organ Failure Assessment (SOFA) scores
- VAP or VHAP developed AKI, ARDS, multiple organ failure or septic shock more often
Original publication
European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI. Intensive Care Med. Published 9 October 2023. doi:10.
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