Anesthesia Type during Cancer Surgery: Results of the General Anesthetics in Cancer Resection (GA-CARES) Randomized, Multicenter Trial
Primary result · All-cause mortalityResult — go to the resultHazard ratio 1.16 95% CI 0.96–1.41Authors' conclusion
Propofol-based anesthesia is not effective at improving cancer-related outcomes in patients undergoing resection of malignancies.
Study context
- Population
- Adults at five US centers undergoing surgical resection of cancers associated with poor outcomes (pancreas, esophagus, lung, stomach, bile ducts, liver, bladder, or peritoneal surface)1,763 ITT
- Participants
- 1,766 adults
- Comparison
- Propofol vs volatile agent for maintenance of GA
- Propofoln = 881
- Volatilen = 882reference
- Primary endpoint
- All-cause mortality
- Follow-up
- Minimum 2-yr
Methodological detailsmulticentre, pragmatic, investigator-initiated, partially blinded, superiority, 95.9% of patients who had surgery received the assigned anesthetic exclusively
- Multicentre
- Pragmatic
- Investigator-initiated
- Partially blinded
- Superiority
- 95.9% of patients who had surgery received the assigned anesthetic exclusively
Primary result
As reported in the abstract
Hazard ratio
1.16
95% CI 0.96–1.41
P = 0.115
Events by treatment group
Propofol vs Volatile
HR 1.16 (95% CI 0.96–1.41); P = 0.115
Secondary outcomes
| Outcome | Propofol | Volatile | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| All-cause mortality, per-protocol population (death through 2-yr follow-up)HR of death | 25.5% | 20% | 1.31 (1.05–1.64) | P = 0.017 | |
| 0.512Hazard ratio (log scale) |
- All-cause mortality, per-protocol population (death through 2-yr follow-up): per-protocol population (n = 1,411)
Disease-free survival
- Results similar to the primary endpoint for disease-free survival
- Consistent across numerous subgroups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Anesthesia Type during Cancer Surgery: Results of the GA-CARES Randomized, Multicenter Trial. Anesthesiology. Published 9 December 2025. doi:10.
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