Perioperative medicine & outcomes
Anesthetic approaches and 2-year recurrence rates in non-muscle invasive bladder cancer: a randomized clinical trial
Authors' conclusion
A notable reduction in the 2-year recurrence rate was observed in patients who underwent SA than in those who underwent GA.
Study context
- Population
- Patients with clinical non-muscle invasive bladder cancer (NMIBC) undergoing transurethral resection of the bladder tumor, Seoul National University Hospital, 2018–2020272 modified ITT
- Participants
- 287 patients
- Comparison
- Spinal anesthesia (SA) vs general anesthesia (GA)
- Primary endpoint
- Disease recurrence
- Follow-up
- 2 years after resection
Methodological detailsprospective, single-centre, 15 patients required alternative anaesthesia (e.g. SA failure, significant obturator reflex)
- Prospective
- Single-centre
- 15 patients required alternative anaesthesia (e.g. SA failure, significant obturator reflex)
Primary result
As reported in the abstract
Recurrence of NMIBC (cumulative incidence) · 2 years
Secondary outcomes
Recurrence of NMIBC, modified ITT population · 2 years · modified intention-to-treat
Disease progression · 2 years
Recurrence of NMIBC, modified ITT population · 2 years
- Significantly lower recurrence with SA vs GA
Disease progression · 2 years
- Difference not statistically significant
Original publication
Anesthetic approaches and 2-year recurrence rates in non-muscle invasive bladder cancer: a randomized clinical trial. Reg Anesth Pain Med. Published 31 December 2024. doi:10.
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