Perioperative medicine & outcomes
Desflurane versus sevoflurane anesthesia and postoperative recovery in older adults undergoing minor- to moderate-risk noncardiac surgery – A prospective, randomized, observer-blinded, clinical trial
Authors' conclusion
Despite previous reports, we did not observe significant faster recovery times after desflurane anesthesia.
Study context
- Population
- Patients ≥65 years scheduled for minor- to moderate-risk noncardiac surgery
- Participants
- 190 patients
- Comparison
- Desflurane vs sevoflurane for maintenance of anaesthesia
- Desfluranen = 95
- Sevofluranen = 95reference
- Primary endpoint
- Time to anesthesia recovery: time from post-anesthesia care unit (PACU) arrival to PACU discharge criteria (modified Aldrete score ≥ 12 points)
Methodological detailssingle-centre, prospective, observer-blinded
- Single-centre
- Prospective
- Observer-blinded
Primary result
As reported in the abstract
Duration of postoperative recovery
Desflurane
0
median · IQR 0–0 · min
Sevoflurane
0
median · IQR 0–0 · min
P = 0.245
Further findings
Aldrete score ≥12 points on PACU arrival
P = 0.277
| Outcome | P value |
|---|---|
| Postoperative BIS values · PACU stayNo significant difference | P = 0.197 |
| Postoperative maximum S100B concentrationsNo significant difference | P = 0.821 |
Safety
| Outcome | P value |
|---|---|
| PONV · PACU stay and first three postoperative daysNo significant difference | P = 0.606 |
Original publication
Desflurane versus sevoflurane anesthesia and postoperative recovery in older adults undergoing minor- to moderate-risk noncardiac surgery – A prospective, randomized, observer-blinded, clinical trial. J Clin Anesth. Published 8 August 2024. doi:10.
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