Pediatric anesthesia & critical care
Anesthetic‐sparing effect of dexmedetomidine during total intravenous anesthesia for children undergoing dental surgery: A randomized controlled trial
Authors' conclusion
Dexmedetomidine 1 mcg/kg reduced the propofol and remifentanil requirements during maintenance of anesthesia in children when administered as a postinduction bolus.
Study context
- Population
- Children aged 2–10 years undergoing elective dental surgery under fixed-ratio propofol–remifentanil TIVAavailable for analysis
- Participants
- 67 children
- Comparison
- Postinduction dexmedetomidine bolus 0.25, 0.5 or 1 mcg/kg vs placebo during propofol–remifentanil TIVA
- Primary endpoint
- Time-averaged maintenance infusion rates of propofol and remifentanil
Methodological detailsdouble-blind, four-arm, BIS-guided TIVA algorithm
- Double-blind
- Four-arm
- BIS-guided TIVA algorithm
Primary result
As reported in the abstract
Percent change (propofol infusion rate)
−10.0%
95% CI −2.4 to −19.8P = 0.013
1 mcg/kg
Percent change (remifentanil infusion rate)
−13.7%
95% CI −5.47 to −21.0P = 0.022
1 mcg/kg
Secondary outcomes
PACU pain and sedation scores, time to discharge
- No differences in pain or sedation scores; time to discharge not significantly prolonged in any dexmedetomidine group
Original publication
Anesthetic‐sparing effect of dexmedetomidine during total intravenous anesthesia for children undergoing dental surgery: A randomized controlled trial. Paediatr Anaesth. Published 28 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →