Angiopoietin-2 as a prognostic biomarker in septic adult patients: a systemic review and meta-analysis
Pooled result · Ang-2 levelsResult — go to the resultSMD 1.08 95% CI 0.68–1.49Authors' conclusion
Ang-2 level was positively correlated with risk of death in sepsis patients.
Study context
- Population
- Septic adult patients
- Participants
- 4,703 patients · 33 studies
- Comparison
- Ang-2 levels in non-survivors vs survivors
- Outcome
- Prognostic significance of Ang-2 in predicting mortality
Methodological detailsNewcastle-Ottawa scale (NOS) quality: one study medium quality, the rest high quality
- NOS quality: one study medium quality, the rest high quality
Pooled result
Ang-2 levels
SMD
1.08
95% CI 0.68–1.49
P < 0.001
Non-survivors vs Survivors
SMD 1.08 (95% CI 0.68–1.49); P < 0.001
As reported in the abstract
- Ang-2 a risk factor for mortality (OR)
- 1.16 (95% CI 1.09-1.23, P < 0.001)
- Ang-2 predicted mortality (AUC)
- 0.76 (95% CI 0.70-0.82, P < 0.001)
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Ang-2 levels, sepsis 3.0 criteria (subgroup) | 0.63 (0.11–1.14) | P = 0.017 | |
| −0.500.511.5Difference (linear scale) |
Ang-2 levels by follow-up duration, sample source, study type, region (subgroup)
- Results independent of duration of follow-up, sample sources, type of study, and region
Original publication
Angiopoietin-2 as a prognostic biomarker in septic adult patients: a systemic review and meta-analysis. Ann Intensive Care. Published 10 November 2024. doi:10.
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