Early plasma angiopoietin-2 is prognostic for acute respiratory distress syndrome (ARDS) and mortality among critically ill patients with sepsis
Authors' conclusion
We found that early plasma Ang-2 in sepsis was associated with higher baseline severity of illness, the development of ARDS, and mortality risk.
Study context
- Population
- Critically ill patients with sepsis enrolled in the ED or early in their ICU course before the COVID-19 pandemic267 with ARDS
- Participants
- 757 patients
- Exposure
- Early plasma Ang-2 levels
- Outcome
- Development of ARDS and 30-day mortality
- Follow-up
- 30 days
Methodological detailsmultivariable models
- Multivariable models
Main finding
As reported in the abstract
Association of early plasma Ang-2 with ARDS and mortality
- Early plasma Ang-2 associated with higher baseline severity of illness, development of ARDS, and mortality risk
Observational data: associations, not effects.
Further findings
| Outcome | ARDS and sepsis | Sepsis alone |
|---|---|---|
| Mortality per log Ang-2 increase, ARDS and sepsis vs sepsis alone (subgroup) | ||
| OR per log Ang-2 increase | 1.81 | 1.52 |
Mortality per log Ang-2 increase, ARDS and sepsis vs sepsis alone (subgroup)
- Association between Ang-2 and mortality strongest among patients with ARDS and sepsis
Original publication
Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis. Crit Care. Published 13 June 2023. doi:10.
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