Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation
Authors' conclusion
Molecular subphenotypes previously identified in AKI are also identifiable in sepsis and respond differently to fluid resuscitation strategy.
Study context
- Population
- Patients with sepsis enrolled in the CLOVERS trial with plasma collected at enrollment
- Participants
- 1,289 patients
- Comparison
- Liberal vs restrictive fluid strategy, by molecular subphenotype
- SP1n = 1,016
- SP2n = 273
Methodological detailssubphenotype by treatment interaction analysis
- Subphenotype by treatment interaction analysis
Primary result
As reported in the abstract
28-day mortality by subphenotype · 28 days
Further findings
Poor clinical outcomes, SP2 vs SP1
- Greater risk in SP2 than SP1, independent of demographics, comorbidities and illness severity scores
Days free from ventilation, RRT and vasopressors (SP2)
- Fewer days in SP2 with liberal vs restrictive strategy
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation. Am J Respir Crit Care Med. Published 1 September 2025. doi:10.
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