Parsimonious Subphenotyping Algorithms Perform Differently in Patients With Sepsis and Hematologic Malignancy
Main finding · Effect modification of subphenotype–mortality association by hematologic malignancyResult — go to the resultHazard ratio 1.50 95% CI 1.08–2.07Study context
- Population
- ICU patients >18 y admitted with a primary indication of sepsis, cohort enriched for active malignancy, single US quaternary referral center396 (42%) active malignancy
- Participants
- 930 patients
- Exposure
- IL-6 algorithm vs IL-8 algorithm
- Outcome
- Effect modification of subphenotype–mortality association by hematologic malignancy
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
1.50
95% CI 1.08–2.07
P = 0.014
IL-8-assigned hyperinflammatory subphenotype
HR 1.50 (95% CI 1.08–2.07); P = 0.014
Observational data: associations, not effects.
Further findings
Hyperinflammatory subphenotype assignment in hematologic malignancy
Hyperinflammatory subphenotype assignment in hematologic malignancy
- Leukemia and neutropenia overrepresented among IL-8-assigned hyperinflammatory
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Parsimonious Subphenotyping Algorithms Perform Differently in Patients With Sepsis and Hematologic Malignancy. Crit Care Med. Published 10 July 2025. doi:10.
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