Immunosuppression at intensive care unit (ICU) admission is not associated with a higher incidence of ICU-acquired bacterial bloodstream infections: the COCONUT study
Authors' conclusion
The 28-day cumulative incidence of ICU-acquired bacterial BSI was not statistically different between patients with and without immunosuppression at ICU admission.
Study context
- Population
- Adults in the ICU of Lille University-affiliated hospital for > 48 h, France, 2020
- Participants
- 1,313 adults
- Exposure
- Immunocompromised vs non-immunocompromised patients at ICU admission
- Immunocompromisedn = 271
- Outcome
- Cumulative incidence of ICU-acquired bacterial BSI
- Follow-up
- 28 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Not statistically different between immunocompromised and non-immunocompromised patients, before and after adjustment for pre-specified baseline confounders
Observational data: associations, not effects.
Secondary outcomes
Microbiology of ICU-acquired bacterial bloodstream infections (BSI)
- Distribution of bacteria comparable between groups; majority Gram-negative bacilli
- ≈64.1%
- Proportion of multidrug-resistant bacteria similar between groups
Outcomes associated with ICU-acquired bacterial BSI
- BSI associated with longer ICU LOS and longer invasive mechanical ventilation, no significant association with mortality; immune status did not modify these associations
Original publication
Immunosuppression at ICU admission is not associated with a higher incidence of ICU-acquired bacterial bloodstream infections: the COCONUT study. Ann Intensive Care. Published 5 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →