Relationship between immunosuppression and intensive care unit-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter cohort study
Main findingResult — go to the resultAdjusted incidence ratio 0.68 95% CI 0.52–0.91Authors' conclusion
Immunocompromised patients had a significantly lower incidence rate of a composite outcome including ICU-MDR-col and/or ICU-MDR-inf.
Study context
- Population
- Consecutive patients with intensive care unit (ICU) stay > 48 h in 8 ICUs in France (single-bed rooms), followed for 28 days
- Participants
- 750 patients · 8 ICUs
- Exposure
- Immunocompromised vs non-immunocompromised patients
- Immunocompromisedn = 264
- Outcome
- Incidence rate of composite of:
- ICU-acquired MDR bacteria colonization
- Infection (ICU-MDR-col and/or ICU-MDR-inf)
Methodological detailsobservational, multicentre
- Observational
- Multicentre
Main finding
As reported in the abstract
Adjusted incidence ratio
0.68
95% CI 0.52–0.91
Observational data: associations, not effects.
Further findings
ICU-MDR-col and ICU-MDR-inf separately
- Difference significant for ICU-MDR-col, not for ICU-MDR-inf
Distribution of multidrug-resistant (MDR) bacteria
- Comparable between groups; majority Enterobacteriacae resistant to third-generation cephalosporins
- ≈74%
Original publication
Relationship between immunosuppression and intensive care unit-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter cohort study. Intensive Care Med. Published 2 January 2023. doi:10.
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