Diabetes and Atherosclerotic Cardiovascular Disease Modify the Association Between Soluble Tumor Necrosis Factor Receptor 1 and Sepsis Mortality: A Secondary Cohort Analysis
Authors' conclusion
Diabetes or ASCVD attenuated the association between sTNFR1 and sepsis mortality.
Study context
- Population
- Adults with sepsis and respiratory failure or vasopressor-dependent shock with baseline sTNFR1 measurements, US academic hospitals
- Participants
- 466 adults
- Comparison
- Diabetes or atherosclerotic cardiovascular disease (ASCVD) vs Without diabetes or ASCVD
- Diabetes or ASCVDn = 243
- Primary endpoint
- Interaction between sTNFR1 and DM or ASCVD on mortality
- Follow-up
- 90 days
Methodological detailsCox regression with restricted cubic splines, adjusted for illness severity, age (in tertiles), and sex
- Cox regression with restricted cubic splines
- Adjusted for illness severity, age (in tertiles), and sex
Primary result
As reported in the abstract
Association of sTNFR1 with 90-day mortality (subgroup)
Estimate (95% CI)
Without diabetes or ASCVD
HR per SD sTNFR1 2.25(1.76–2.88)
Diabetes or ASCVD vs Without diabetes or ASCVDplateau in mortality risk above ≈12,000 pg/mL
HR(overall) 1.04 (0.83–1.30)
Further findings
Baseline sTNFR1
Illness severity and mortality
- Similar between groups
Interaction for interleukin-6 or angiopoietin-2
- Interaction specific to sTNFR1; not observed for interleukin-6 or angiopoietin-2
Obesity or hypertension without DM or ASCVD (subgroup)
- No effect modification
Original publication
Diabetes and Atherosclerotic Cardiovascular Disease Modify the Association Between Soluble Tumor Necrosis Factor Receptor 1 and Sepsis Mortality: A Secondary Cohort Analysis. Crit Care Med. Published 30 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →