Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial
Primary result · 90-day mortality by hypothermia at inclusionResult — go to the resultHazard ratio 1.92 95% CI 1.38–2.67Authors' conclusion
In patients with septic shock, hypothermia at inclusion and persistence of hypothermia during the first 24 h were associated with higher mortality at day 90.
Study context
- Population
- Patients with septic shock enrolled within 6 h of vasopressor initiation in the SEPSISPAM trial
- Participants
- 691 patients
- Comparison
- Hypothermia at inclusion vs no hypothermia at inclusion; temperature trajectories during the first 24 h
- Hypothermia at inclusionn = 103
- Primary endpoint
- Mortality
- Follow-up
- Day 90
Methodological detailspost-hoc analysis
- Post-hoc analysis
Primary result
90-day mortality by hypothermia at inclusion
Hazard ratio
1.92
95% CI 1.38–2.67
P < 0.001
Hypothermia at inclusion vs No hypothermia at inclusion
HR 1.92 (95% CI 1.38–2.67); P < 0.001
As reported in the abstract
Further findings
| Outcome | Without hypothermia | Transient hypothermia | Persistent hypothermia | HR (CI) | P value | |
|---|---|---|---|---|---|---|
| 90-day mortality by temperature trajectoryPersistent hypothermia vs Without hypothermia | 40% | 49% | 78.3% | 2.83 (1.62–4.95) | P < 0.0001 | |
| Proportion of patients | 86.6% | 10% | 3.4% | |||
| 0.20.5125Hazard ratio (log scale) |
Original publication
Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial. Ann Intensive Care. Published 18 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →