Distinct immune profiles and clinical outcomes in sepsis subphenotypes based on temperature trajectories
Authors' conclusion
Sepsis subphenotypes identified using the universally available measurement of body temperature had distinct immune profiles. Hypothermic patients, who had the highest mortality rate, also had the lowest levels of most pro- and anti-inflammatory cytokines.
Study context
- Population
- Hospitalised patients with suspicion of infection, four hospitals, 2018–2022
- Participants
- 3,576 patients
- Exposure
- Temperature trajectory subphenotypes: hyperthermic slow resolvers, hyperthermic fast resolvers, normothermic, hypothermic
- Hyperthermic slow resolversn = 563
- Hyperthermic fast resolversn = 805
- Normothermicn = 1,693
- Hypothermicn = 515
- Outcome
- Mortality
Methodological detailsfour hospitals
- Four hospitals
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Biomarkers (31 tested)
- Biomarkers significantly different between temperature trajectories after multiple testing correction
- 20
- Hyperthermic fast and slow resolvers had the highest levels of most pro- and anti-inflammatory cytokines
- Hypothermics had suppressed levels of most cytokines but the highest levels of several coagulation markers (Ang-1, thrombomodulin, tissue factor)
Original publication
Distinct immune profiles and clinical outcomes in sepsis subphenotypes based on temperature trajectories. Intensive Care Med. Published 9 October 2024. doi:10.
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