Antibiotic prophylaxis in emergency cholecystectomy for mild to moderate acute cholecystitis: a systematic review and meta-analysis of randomized controlled trials
Authors' conclusion
Perioperative antibiotics in patients with mild to moderate acute cholecystitis did not show a significant reduction of postoperative infectious complications after emergency cholecystectomy.
Study context
- Population
- Patients with mild to moderate acute cholecystitis (Tokyo guidelines) undergoing emergency cholecystectomy
- Participants
- 1,747 patients · 7 randomized controlled trials (RCTs)
- Comparison
- Perioperative prophylactic antibiotics vs placebo
- Outcome
- Total postoperative infectious complications (PIC)
Pooled result
As reported in the abstract
Total PIC
No significant difference in total postoperative infectious complications (PIC), antibiotics vs placebo: RR (95% CI), P
0.84
0.63, 1.12P = 0.23
Further pooled results
Surgical site infection
- No significant difference, antibiotics vs placebo: RR (95% CI), P
- 0.79 (0.56, 1.12), P = 0.19
Distant infections
- No significant difference, antibiotics vs placebo: RR (95% CI), P
- 1.01 (0.55, 1.88), P = 0.97
Readmission
- No significant difference, antibiotics vs placebo: RR (95% CI), P
- 0.69 (0.43, 1.11), P = 0.13
Mortality
- No significant difference, antibiotics vs placebo: RR (95% CI), P
- 0.34 (0.04, 3.23), P = 0.35
Safety
Non-infectious complications
- No significant difference, antibiotics vs placebo: RR (95% CI), P
- 0.84 (0.64, 1.11), P = 0.22
Original publication
Antibiotic prophylaxis in emergency cholecystectomy for mild to moderate acute cholecystitis: a systematic review and meta-analysis of randomized controlled trials. Perioper Med (Lond). Published 9 August 2024. doi:10.
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