Single- vs Multiple-Dose Antibiotic Prophylaxis for Total Hip Arthroplasty
Authors' conclusion
In this study, a single preoperative antibiotic dose was noninferior to multiple doses for preventing PJI.
Study context
- Population
- Patients undergoing primary total hip arthroplasty (THA) for osteoarthritis at all hospitals performing THA in Denmark, 2010–2020
- Participants
- 76,126 patients
- Exposure
- Single-dose vs Multiple-dose
- Single-dosen = 6,409
- Multiple-dosen = 69,717reference
- Outcome
- PJI (microbiologically confirmed infection or clinical diagnosis recorded at revision surgery)
- Follow-up
- 90 days
Methodological detailstarget trial emulation, population-based, multicenter cohort, registry-based, stabilized inverse probability of treatment weighting, noninferiority
- Target trial emulation
- Population-based
- Multicenter cohort
- Registry-based
- Stabilized inverse probability of treatment weighting
- Noninferiority
Main finding
As reported in the abstract
PJI within 90 days
Observational data: associations, not effects.
Secondary outcomes
Periprosthetic joint infection (PJI) at 90 and 365 days, secondary outcomes (sensitivity analyses)
- Consistent results across secondary outcomes and unadjusted, weighted and propensity score-matched analyses
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Single- vs Multiple-Dose Antibiotic Prophylaxis for Total Hip Arthroplasty. JAMA Netw Open. Published 1 September 2026. doi:10.
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