Anticoagulation Monitoring Using Activated Clotting Time in Patients Receiving Extracorporeal Membrane Oxygenation: A Meta-Analysis of Correlation Coefficients
Authors' conclusion
Even though ACT is a widely used UFH monitoring tool in ECMO patients, our meta-analysis found a weak correlation between ACT and UFH infusion dose.
Study context
- Population
- Patients receiving extracorporeal membrane oxygenation (ECMO) support19 studies
- Outcome
- Correlation between activated clotting time (ACT) and unfractionated heparin (UFH) infusion dose
Methodological detailsretrospective and prospective studies
- Retrospective and prospective studies
Pooled result
As reported in the abstract
Pooled correlation coefficient (weak correlation; n = 12,625 samples)
0.132
95% CI 0.03–0.23
Further pooled results
In-hospital mortality
- Patients who died during hospital stay
- 47%
Safety
Adverse events (pooled incidence)
- Hemorrhage
- 45%
- Thrombosis
- 30%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Anticoagulation Monitoring Using Activated Clotting Time in Patients Receiving Extracorporeal Membrane Oxygenation: A Meta-Analysis of Correlation Coefficients. J Cardiothorac Vasc Anesth. Published 5 August 2024. doi:10.
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