ICU sedation, delirium & recovery
Antipsychotics in the Treatment of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*
Pooled result · Delirium- or coma-free daysResult — go to the resultMean difference 0.90 d 95% CI −0.32 to 2.12Authors' conclusion
In conclusion, our systematic review and meta-analysis demonstrated with moderate certainty that there is no difference in delirium- or coma-free days when delirious critically ill adults are treated with antipsychotic medications.
Study context
- Population
- Critically ill adults with delirium
- Participants
- 1,750 adults · 5 randomized controlled trials (RCTs)
- Comparison
- Antipsychotic medications vs usual care or placebo
- Outcome
- Delirium- or coma-free days
Methodological detailsparallel-group RCTs
- Parallel-group RCTs
Pooled result
As reported in the abstract
Mean difference
0.90 d
95% CI −0.32 to 2.12
Antipsychotics vs Usual care or placebo
mean difference 0.90 d (95% CI −0.32 to 2.12)
Further pooled results
Mortality, duration of mechanical ventilation, ICU and hospital LOS
- No difference
Typical vs atypical antipsychotics (subgroup)
- No subgroup effect for any outcome
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Adverse eventsHigh certainty | 1.27 (0.71–2.30) | |
| 0.512Relative risk (log scale) |
Original publication
Antipsychotics in the Treatment of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*. Crit Care Med. Published 15 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →