ICU sedation, delirium & recovery
Variation in Use of Medications for Opioid Use Disorder in Critically Ill Patients Across the United States
Authors' conclusion
In a large multicenter, retrospective study, there was large variation in the use of MOUD among ICU patients with a history of OUD.
Study context
- Population
- Adults (≥ 18 yr) with a history of opioid use disorder (OUD) admitted to US ICUs, 2016–2020
- Participants
- 108,189 adults · 658 hospitals
- Outcome
- Received MOUD
Methodological detailsmulticentre, observational, Premier AI Healthcare Database
- Multicentre
- Observational
- Premier AI Healthcare Database
Main finding
As reported in the abstract
- Received MOUD
- 20,508 (19.0%)
- Methadone, among MOUD recipients
- 13,745 (67.0%)
- Buprenorphine, among MOUD recipients
- 2,950 (14.4%)
- Buprenorphine/naloxone, among MOUD recipients
- 4,227 (20.6%)
- MOUD use per hospital, median (IQR; range)
- 16.0% (10-24; 0-70.0%)
- Variation in MOUD use explained by admitting hospital
- 8.9%
Observational data: associations, not effects.
Further findings
Factors associated with receiving MOUD in the ICU
| aOR (95% CI) | ||
|---|---|---|
| Primary admitting diagnosis of unintentional poisoning | 0.41 (0.38–0.45) | |
| Additional substance use disorder | 0.66 (0.64–0.68) | |
| 0.20.5125Adjusted odds ratio (log scale) |
MOUD use among patients on invasive mechanical ventilation
- MOUD use
- 37.9%
MOUD initiation and duration
- Median day of MOUD initiation, hospital day (IQR)
- 2 (1-3)
- Median duration of MOUD use, days (IQR)
- 4 (2-8)
Factors associated with receiving MOUD in the ICU
- Factors indicating greater severity of illness associated with reduced odds of receiving MOUD
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Variation in Use of Medications for Opioid Use Disorder in Critically Ill Patients Across the United States. Crit Care Med. Published 19 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →