ICU sedation, delirium & recovery
Epidemiology of Substance-Related Admissions to ICUs in the United States
Authors' conclusion
A substantial burden of substance-related diagnoses exists in patients admitted to ICUs. Alcohol use was most common and associated with increased hospital mortality relative to other substances. Rates of substance-related ICU admission differed by age, sex, race, and ethnicity.
Study context
- Population
- Adult ICU admissions with an ICD-10 diagnosis of a substance-related disorder not in remission, US ICUs in the Premier Healthcare Database, 2016–2019
- Participants
- 4,740,799 ICU admissions
- Outcome
- Prevalence of substance-related ICU admissions
Methodological detailsmulticentre, nationally representative database
- Multicentre
- Nationally representative database
Main finding
As reported in the abstract
Substance-related diagnosis (760,153 admissions; ≈1 in 6 ICU admissions), 95% CI 16.00-16.07%
16.0%
Alcohol-related (most common), % of all encounters, 95% CI 8.87-8.92%
8.9%
Opioid-related, 95% CI 3.97-4.01%
4.0%
Stimulant-related, 95% CI 2.91-2.94%
2.9%
Observational data: associations, not effects.
Further findings
Predictors of in-hospital mortality after substance-related ICU admission
| aOR (95% CI) | ||
|---|---|---|
| Alcohol-related diagnosesMultivariable analysis adjusting for relevant covariates | 1.12 (1.06–1.19) | |
| Female sexMultivariable analysis adjusting for relevant covariates | 1.07 (1.04–1.09) | |
| Non-Hispanic ethnicityMultivariable analysis adjusting for relevant covariates | 1.08 (1.01–1.16) | |
| 0.512Adjusted odds ratio (log scale) |
Demographics of substance-related ICU admissions
- Higher rates in patients 55-64 yr, male, non-Hispanic and "Other" race
- Opioid-related rates higher in White patients; stimulant-related rates higher in Black patients
Heroin use among opioid-related ICU admissions
- Heroin use identified, 95% CI 6.37-6.60%
- 6.5%
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →