ICU sedation, delirium & recovery
Exposure to Antipsychotic Medication Is Associated With Less Days Alive and Free From Catatonia in Critically Ill Patients
Study context
- Population
- Critically ill adults on mechanical ventilation or vasopressors without major neurocognitive disorder, severe psychiatric disorder or catatonia at baseline; medical, surgical and trauma ICUs
- Participants
- 270 adults
- Exposure
- Antipsychotic exposure vs never exposed
- Exposedn = 102
- Outcome
- Catatonia-free days (CFDs): days alive and free from catatonia
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds of more CFD
Exposed vs Never exposedOdds ratio (95% CI)
5-day model; 74% reduction
0.2568(0.1580–0.4173)
14-day model; 51% reduction
0.4939(0.3857–0.6325)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Odds of more CFD, higher vs lower antipsychotic dosageHigher dosage vs Lower dosage · 5-day model; 97% reduction | 0.0281 (0.0142–0.0556) | |
| Odds of more CFD, higher vs lower antipsychotic dosageHigher dosage vs Lower dosage · 14-day model; 97% reduction | 0.0335 (0.0166–0.0673) | |
| 0.050.21520Odds ratio (log scale) |
- Catatonia among exposed
- 26% · 27 of 102
Original publication
Exposure to Antipsychotic Medication Is Associated With Less Days Alive and Free From Catatonia in Critically Ill Patients. Crit Care Med. Published 10 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →