Approaches to neuropathic amputation-related pain: narrative review of surgical, interventional, and medical treatments
Authors' conclusion
Multimodal approaches combining pharmacotherapy, surgery and invasive neuromodulation procedures would appear to be the most promising strategy for preventive and treating PLP and RLP.
Study context
- Population
- Patients with neuropathic amputation-related pain (phantom limb pain, residual limb pain, or both)
- Comparison
- Surgical, interventional and medical treatments for neuropathic amputation-related pain
Main finding
As reported in the abstract
- Evidence supporting most if not all interventions for phantom limb pain (PLP) inconclusive and lacking high certainty
- Targeted muscle reinnervation and regional peripheral nerve interface are the leading surgical options for reducing neuroma formation and PLP
- Non-surgical options (pharmaceutical therapy, regional interventional techniques, behavioral therapies) can benefit certain patients
- Growing evidence that neuromodulation at the spinal cord, dorsal root ganglia and/or peripheral nerves can be an adjuvant therapy for PLP
Original publication
Approaches to neuropathic amputation-related pain: narrative review of surgical, interventional, and medical treatments. Reg Anesth Pain Med. Published 2 February 2024. doi:10.
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