Are changes in antibiotic prophylaxis recommendations responsible for an increased risk of cefazolin allergy?
Authors' conclusion
Direct previous cefazolin exposure was identified in 78% of cefazolin-allergic patients.
Study context
- Population
- Patients with skin test-proven cefazolin allergy at a specialized allergy centreanswered the questionnaire
- Participants
- 14 patients
- Outcome
- Sensitization agents towards cefazolin (structurally similar drugs and previous cefazolin exposure)
Methodological detailsself-administered anonymous questionnaire, single specialized allergy centre
- Self-administered anonymous questionnaire
- Single specialized allergy centre
Main finding
As reported in the abstract
Molecules similar to cefazolin (score≥0.7; all cephalosporins)
42
Similar molecules marketed in France
8
Patients reporting exposure to any identified antibiotic
0
Patients with ≥1 previous surgery requiring cefazolin before the index case
11
78%
Observational data: associations, not effects.
Original publication
Are changes in antibiotic prophylaxis recommendations responsible for an increased risk of cefazolin allergy? Anaesth Crit Care Pain Med. Published 24 January 2024. doi:10.
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