Cardiac arrest & resuscitation
Arterial blood gas parameters during cardiopulmonary resuscitation and sustained return of spontaneous circulation in out-of-hospital cardiac arrest: a preplanned secondary analysis of the Augmented-Medication CardioPulmonary Resuscitation (AMCPR) trial
Authors' conclusion
During monitored ED resuscitation for OHCA, higher intra-arrest PaO2 was associated with sustained ROSC, although this association was only partly separable from resuscitation duration.
Study context
- Population
- Adult out-of-hospital cardiac arrest (OHCA) patients treated at a tertiary ED with arterial blood gas analysis (ABGA) during cardiopulmonary resuscitation (CPR)135 with 10-min sample
- Participants
- 251 patients
- Comparison
- Intra-arrest PaO2 at 10 min and sustained return of spontaneous circulation (ROSC)
- Primary endpoint
- Sustained ROSC (exposure: PaO2 at protocol-defined 10-min time point)
- Follow-up
- 10 min
Methodological detailspreplanned, single tertiary ED
- Preplanned
- Single tertiary ED
Primary result
As reported in the abstract
Sustained ROSC per PaO2 at 10 min
Higher PaO2 at 10 min independently associated with sustained ROSC
aOR 1.02
95% CI 1.01–1.02
Further findings
Sustained ROSC (all patients)
- Achieved sustained ROSC, 93 patients
- 37.1%
Optimal cut-offs (secondary exploratory)
- PaO2 cut-off
- >60 mmHg
- PaCO2 cut-off
- <70 mmHg
- pH and lactate showed no consistent pattern
Survival to discharge
- Survived to discharge, 20 patients
- 8.0%
Favorable neurological outcome
- Favorable neurological outcome, 2 patients
- 0.8%
Original publication
Arterial blood gas parameters during cardiopulmonary resuscitation and sustained return of spontaneous circulation in out-of-hospital cardiac arrest: a preplanned secondary analysis of the AMCPR trial. Resuscitation. Published 14 August 2026. doi:10.
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