Cardiothoracic & vascular anesthesia
Arterial Hyperoxemia During Cardiopulmonary Bypass Was Not Associated With Worse Postoperative Pulmonary Function: A Retrospective Cohort Study
Main finding · Postoperative P/F ratioResult — go to the resultEstimated increase 4.61 95% CI 0.71–8.50Authors' conclusion
Our investigation found no clinically significant association between Pa o2 during CPB and postoperative lung function.
Study context
- Population
- Patients undergoing elective cardiac surgery (coronary artery bypass, valve, aortic, or combined) requiring cardiopulmonary bypass (CPB), April 2015–December 2021, large quaternary medical center8,429 (92.2%) analysed
- Participants
- 9,141 patients
- Exposure
- PaO2 during CPB as continuous exposure
- Outcome
- Postoperative lung function: PaO2/FiO2 (P/F) ratio
- Follow-up
- 6 hours following surgery or before extubation
Methodological detailssingle-centre
- Single-centre
Main finding
Postoperative P/F ratio
Estimated increase
4.61
95% CI 0.71–8.50
P = 0.02
100-unit increase in Pa o2
estimated increase 4.61 (95% CI 0.71–8.50); P = 0.02
As reported in the abstract
Observational data: associations, not effects.
Further findings
Peak lactate 6 hours post CPB
| GMR (98.3% CI) | P value | ||
|---|---|---|---|
| Pa o2 | 1.01 (0.98–1.03) | P = 0.55 | |
| 0.512Geometric mean ratio (log scale) |
Average lactate 6 hours post CPB
| GMR (98.3% CI) | P value | ||
|---|---|---|---|
| Pa o2 | 1.00 (0.97–1.03) | P = 0.93 | |
| 0.512Geometric mean ratio (log scale) |
AKI by Kidney Disease Improving Global Outcomes (KDIGO) criteria
| OR (98.3% CI) | P value | ||
|---|---|---|---|
| Pa o2 | 0.91 (0.75–1.10) | P = 0.23 | |
| 0.512Odds ratio (log scale) |
Original publication
Arterial Hyperoxemia During Cardiopulmonary Bypass Was Not Associated With Worse Postoperative Pulmonary Function: A Retrospective Cohort Study. Anesth Analg. Published 21 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →