As‐needed opioid dosing for emergency patients with a daily use of opioids
Authors' conclusion
Patients with daily use of opioids presenting in the ED with acute pain had a high risk of inadequate PRN opioid dose, especially if the DDO was high.
Study context
- Population
- Emergency department (ED) patients with daily opioid use who received PRN opioid within 3 h of admission, Aarhus University Hospital, Denmark, February–June 202182 received PRN opioid
- Participants
- 252 patients
- Exposure
- Daily dose of opioids (DDO) <60 mg/day vs DDO ≥60 mg/day
- DDO <60 mg/dayn = 50reference
- DDO ≥60 mg/dayn = 32
- Outcome
- Proportion receiving an inadequate initial PRN opioid dose (<15% of daily dose of opioids)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Inadequate initial PRN opioid dose (<15% of DDO)
Patients receiving a PRN dose of <15% of DDO
33%
27 of 82; 95% CI 23.7–43
Observational data: associations, not effects.
Secondary outcomes
| Outcome | DDO <60 mg/day | DDO ≥60 mg/day | RR (95% CI) | |
|---|---|---|---|---|
| Inadequate PRN dose by DDO (subgroup) | 20% (95% CI 10.0–33.7) | 53.1% (95% CI 34.7–70.9) | 2.65 (1.4–5.1) | |
| 0.20.5125Relative risk (log scale) |
Original publication
As‐needed opioid dosing for emergency patients with a daily use of opioids. Acta Anaesthesiol Scand. Published 25 October 2023. doi:10.
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