Perioperative medicine & outcomes

Assessing the accuracy of Seismofit® as an estimate of preoperative maximal oxygen consumption in patients with hepato-pancreato-biliary, colorectal, and gastro-oesophageal cancer

BJA OpenPublished Prospective observational method-comparison study

Main finding · Linear association, Seismofit® vs CPET VO2 peakResult — go to the resultPearson r 0.111 95% CI −0.242 to 0.437

Authors' conclusion

There was no evidence of linear association between Seismofit®-estimated VO2 peak and objectively measured VO2 peak by CPET in patients undergoing assessment for major abdominal cancer surgery. This finding was consistent across all subgroup and exploratory analyses. Seismofit® tended to overestimate VO2 peak with a high degree of bias.

Study context

Population
Patients with hepato-pancreato-biliary, colorectal, or gastro-oesophageal cancer undergoing preoperative assessmentcompleted both cardiopulmonary exercise testing (CPET) and Seismofit®
Participants
33 patients
Exposure
Seismofit®-estimated vs CPET-measured VO2 peak
Outcome
Relationship between Seismofit®-estimated VO2 peak and CPET-measured VO2 peak
Methodological detailssingle-centre, blinded
  • Single-centre
  • Blinded

Main finding

Linear association, Seismofit® vs CPET VO2 peak

Pearson r

0.111

95% CI −0.242 to 0.437

P = 0.539

As reported in the abstract

Observational data: associations, not effects.

Secondary outcomes

OutcomeBias (95% CI)
Bias and limits of agreement, Seismofit® vs CPETSD 8.8; interval = 95% limits of agreement · large bias12.8 (−4.5 to 30.0)

Association in hepato-pancreato-biliary or gastro-oesophageal subgroup (subgroup)

No association between Seismofit®-estimated and CPET-measured VO2 peak

Association with commonly reported CPET variables

No association between Seismofit®-estimated VO2 peak and commonly reported CPET variables

Original publication

Assessing the accuracy of Seismofit® as an estimate of preoperative maximal oxygen consumption in patients with hepato-pancreato-biliary, colorectal, and gastro-oesophageal cancer. BJA Open. Published 8 April 2025. doi:10.1016/j.bjao.2025.100395

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