Assessing different brain oxygenation components in elderly patients under propofol or sevoflurane anesthesia: A randomized controlled study
Authors' conclusion
In cerebral oximetry, Δo2Hbi and ΔHHbi could emerge as a valuable approach for discerning changes in the underlying baseline status of the brain in elderly patients during anesthesia.
Study context
- Population
- Patients aged 70–80 years, American Society of Anesthesiologists (ASA) I–II, scheduled for urologic surgery under GA100 analysed
- Participants
- 100 patients
- Comparison
- Propofol-based vs sevoflurane anaesthesia
- Propofoln = 50
- Sevofluranen = 50
- Primary endpoint
- Δo2Hbi pattern in the left and right sides within each group
- Follow-up
- 5 to 30 min
Methodological detailsdouble-blind, single-centre, prospective
- Double-blind
- Single-centre
- Prospective
Primary result
As reported in the abstract
Δo2Hbi change from 5 to 30 min
- Propofol, left Δo2Hbi: 1.4 (3.7) at 5 min to −0.1 (1.8) at 30 min, P < 0.0001
- Propofol, right Δo2Hbi: 2.9 (4.2) at 5 min to −0.06 (2.3) at 30 min, P < 0.0001
- Sevoflurane, left Δo2Hbi: 1.1 (3.4) at 5 min to −1.4 (4.4) at 30 min, P < 0.0001
- Sevoflurane, right Δo2Hbi: 2.0 (3.2) at 5 min to −1.2 (3.9) at 30 min, P < 0.0001
- No significant differences between the two groups
Further findings
ΔHHbi
- No significant changes after an initial decrease at 5 min; no significant differences between the two groups
Original publication
Assessing different brain oxygenation components in elderly patients under propofol or sevoflurane anesthesia: A randomized controlled study. J Clin Anesth. Published 12 June 2024. doi:10.
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