Neuroanesthesia & neurocritical care
Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia: A nonrandomised interventional trial
Authors' conclusion
During general anaesthesia, dynamic CA is dependent on MAP, also within the autoregulatory range. This phenomenon was more pronounced during propofol anaesthesia than during sevoflurane.
Study context
- Population
- American Society of Anesthesiologists (ASA) I/II patients undergoing noncardiothoracic, nonneurosurgical and nonlaparoscopic surgery under GA
- Participants
- 26 vs 28
- Comparison
- Propofol vs Sevoflurane
- Propofoln = 26
- Sevofluranen = 28
- Outcome
- Response of dynamic CA (phase lead between MAP and MCA Vmean oscillations) during step-wise MAP increases (60–100 mmHg)
Methodological detailssingle-centre, Enrolment 11 January 2019 to 23 September 2019
- Single-centre
- Enrolment 11 January 2019 to 23 September 2019
Main finding
As reported in the abstract
Change in dynamic CA (phase lead) per mmHg MAP
| Group | Value | P |
|---|---|---|
| Propofol | 0.73 (95% CI 0.51–0.95) ° mmHg −1 | P ≤ 0.001 |
| Sevoflurane | 0.21 (95% CI 0.01–0.42) ° mmHg −1 | P = 0.04 |
Value
Propofol0.73 (95% CI 0.51–0.95) ° mmHg −1
Sevoflurane0.21 (95% CI 0.01–0.42) ° mmHg −1
P
PropofolP ≤ 0.001
SevofluraneP = 0.04
Further findings
| Outcome | P value |
|---|---|
| MCA Vmean during step-wise MAP incrementsMCA Vmean increased more with sevoflurane | P ≤ 0.001 |
Mean arterial pressure (MAP) achieved per step (60–100 mmHg)
- Comparable between anaesthesia regimens
Original publication
Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia: A nonrandomised interventional trial. Eur J Anaesthesiol. Published 6 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →