Anesthetic drugs & techniques

Assessment of explicit and implicit memories during remimazolam anaesthesia using the process dissociation procedure: A prospective cohort study

Eur J AnaesthesiolPublished Prospective cohort study

Authors' conclusion

There was no evidence of explicit or implicit memory formation during remimazolam anaesthesia (BIS 60 to 80).

Study context

Population
Patients undergoing GA with remimazolam, BIS maintained at 60 to 80; tertiary centre, Seoul, South Korea, March–July 2022
Participants
100 patients
Outcome
Probability of explicit or implicit memory formation (process dissociation procedure; original and extended models); memory absent if 95% CI includes 0
Follow-up
Within 24 h after word presentation

Main finding

As reported in the abstract

Probability of explicit memory formation, original model

−0.01 (−0.04 to 0.02) (95% CI includes 0)

Probability of explicit memory formation, extended model

−0.04 (−0.10 to 0.01) (95% CI includes 0)

Probability of implicit memory formation, original model

0.08 (0.06 to 0.10) (95% CI does not include 0)

Probability of implicit memory formation, extended model

0.00 (−0.03 to 0.03) (95% CI includes 0)

Observational data: associations, not effects.

Further findings

Conscious recall (modified Brice interview) · within 1 and 24 h after surgery

No evidence of awareness

Original publication

Assessment of explicit and implicit memories during remimazolam anaesthesia using the process dissociation procedure: A prospective cohort study. Eur J Anaesthesiol. Published 25 September 2023. doi:10.1097/eja.0000000000001904

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