Comparison of recovery profiles between total intravenous anaesthesia with propofol or remimazolam reversed with flumazenil in patients undergoing breast surgery: A randomised controlled trial
Authors' conclusion
Administration of remimazolam with flumazenil may be a promising option for patients undergoing breast cancer surgery, providing faster recovery and better SAS scores than propofol during emergence from general anaesthesia.
Study context
- Population
- Adults (≥19 years) undergoing GA for scheduled breast cancer surgery, tertiary teaching hospital, South Korea, August–December 2022
- Comparison
- Remimazolam reversed with flumazenil vs propofol TIVA
- Primary endpoint
- Time to eye opening to command during recovery from GA
Methodological detailssingle-centre, double-blind, Emergence monitored by only one anaesthesiologist
- Single-centre
- Double-blind
- Emergence monitored by only one anaesthesiologist
Primary result
Time to eye opening to command
Mean difference
187 s
95% CI 133–241
P < 0.001
By group
Remimazolam vs Propofol
mean difference 187 s (95% CI 133–241); P < 0.001
As reported in the abstract
Secondary outcomes
Mean, s
| Outcome | Propofol | Mean difference (s) (95% CI) | P value | |
|---|---|---|---|---|
| Time to SGA removalRemimazolam vs Propofol | 366 (SD 149) | 198 (140–255) | P < 0.001 | |
| Time to discharge from the operating roomRemimazolam vs Propofol | 449 (SD 159) | 206 (145–267) | P < 0.001 | |
| −2000200400Difference, s (linear scale) |
| Outcome | Propofol | P value |
|---|---|---|
| Riker SAS score 4 during emergenceRemimazolam vs Propofol · SAS scores differed significantly | 1 events | P < 0.001 |
- Time to supraglottic airway (SGA) removal: Remimazolam mean 169 (SD 51) s
- Time to discharge from the operating room: Remimazolam mean 243 (SD 55) s
- Riker sedation agitation scale (SAS) score 4 during emergence: Remimazolam 25 events
Original publication
Comparison of recovery profiles between total intravenous anaesthesia with propofol or remimazolam reversed with flumazenil in patients undergoing breast surgery: A randomised controlled trial. Eur J Anaesthesiol. Published 11 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →