Cardiothoracic & vascular anesthesia
Comparison of remimazolam and sevoflurane for general anesthesia during transcatheter aortic valve implantation: a randomized trial
Primary resultResult — go to the resultDifference in medians −6.9 min 95% CI −8.7 to −5.0Authors' conclusion
Compared with sevoflurane, a combination of remimazolam and flumazenil significantly reduced the time to extubation in patients undergoing general anesthesia for TAVI.
Study context
- Population
- Patients undergoing GA for Transcatheter Aortic Valve Implantation (TAVI), Kagoshima University Hospital, June 2022–August 202356 included
- Participants
- 60 patients
- Comparison
- Remimazolam/flumazenil vs sevoflurane for GA maintenance
- Primary endpoint
- Time to extubation
Methodological detailsprospective, parallel-design, open-label, single-centre, Remifentanil infusion 0.2 μg·kg-1·min-1 iv in both groups; anaesthetics adjusted to BIS 40-60
- Prospective
- Parallel-design
- Open-label
- Single-centre
- Remifentanil infusion 0.2 μg·kg-1·min-1 iv in both groups; anaesthetics adjusted to BIS 40-60
Primary result
As reported in the abstract
Difference in medians
−6.9 min
95% CI −8.7 to −5.0
P < 0.001
By group
Remimazolam vs Sevoflurane
difference in medians −6.9 min (95% CI −8.7 to −5.0); P < 0.001
Secondary outcomes
| Outcome | P value |
|---|---|
| Perfusion index | P = 0.03 |
| Regional cerebral oxygen saturation | P = 0.03 |
Perfusion index
- Statistically significant difference between groups
Regional cerebral oxygen saturation
- Statistically significant difference between groups
Other secondary outcomes (hemodynamics, vasopressor dose, intra- and postoperative complications, muscle strength recovery)
- No significant differences between the two groups
Original publication
Comparison of remimazolam and sevoflurane for general anesthesia during transcatheter aortic valve implantation: a randomized trial. Can J Anaesth. Published 23 December 2024. doi:10.
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