Comparison of propofol vs. remimazolam on emergence profiles after general anesthesia: A randomized clinical trial
Primary result · Time to obey verbal commandsResult — go to the resultMedian difference −9 95% CI −11 to −6Authors' conclusion
Remimazolam-based total intravenous anesthesia with flumazenil reversal may be effective in reducing emergence time, but a significant incidence of re-sedation was observed in the PACU.
Study context
- Population
- Adults, American Society of Anesthesiologists (ASA) I–III, undergoing GA
- Participants
- 100 adults
- Comparison
- Remimazolam TIVA with flumazenil reversal vs propofol TIVA
- Primary endpoint
- Time to obey verbal commands
Methodological detailsprospective, double-blind
- Prospective
- Double-blind
Primary result
As reported in the abstract
Median difference
−9
95% CI −11 to −6
P < 0.001
By group
Remimazolam vs Propofol
median difference −9 (95% CI −11 to −6); P < 0.001
Secondary outcomes
| Outcome | P value |
|---|---|
| RASS score upon arrival to the PACUDiffered significantly | P = 0.006 |
Time to BIS over 80 and to laryngeal mask airway (LMA) removal
- Significantly longer in the propofol group
Safety
- Re-sedation in the post-anesthesia care unit (PACU) — Remimazolam
- 22%
Original publication
Comparison of propofol vs. remimazolam on emergence profiles after general anesthesia: A randomized clinical trial. J Clin Anesth. Published 26 July 2023. doi:10.
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