ICU sedation, delirium & recovery
Assessment of sedation by automated pupillometry in critically ill patients: a prospective observational study
Authors' conclusion
Quantitative assessment of %PLR correlates with other indicators of sedation depth in critically ill patients.
Study context
- Population
- Ventilated and sedated critically ill adults, measured at each Richmond Agitation and Sedation Scale (RASS) level from −5 to 0 after discontinuation of hypnotics163 paired measurements
- Participants
- 38 participants
- Exposure
- Automated pupillometry vs RASS and spectral edge frequency (SEF)
- Outcome
- Correlation of %PLR with RASS and with SEF; ability of %PLR to differentiate light, moderate and deep sedation (AUC)
Main finding
As reported in the abstract
- Median %PLR with decreasing sedation depth, from (IQR 17-25%)
- 20%
- Median %PLR with decreasing sedation depth, to (IQR 33-40%); P<0.001
- 36%
- Correlation %PLR vs RASS (Rho)
- 0.635
- Correlation %PLR vs SEF (R)
- 0.641
- AUC, moderate/light vs deep sedation (%PLR threshold 28%; sensitivity 83%, specificity 83%)
- 0.87
- AUC, light vs moderate/deep sedation (threshold 31%; sensitivity 81%, specificity 75%)
- 0.82
Observational data: associations, not effects.
Original publication
Assessment of sedation by automated pupillometry in critically ill patients: a prospective observational study. Br J Anaesth. Published 29 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →